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28 , 17171728.e6 (2019)

Key mechanisms of Nigella sativa in alleviating cardiometabolic diseases Several mechanisms may contribute to the protective cardiometabolic role of Nigella sativa

Oxidized protein disulfide isomerase (PDI) facilitates disulfide bond formation in conjunction with endoplasmic reticulum oxidase 1 (Ero1), while GSH acts as a buffer to maintain the reduced form of PDI [50]