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| | Aggressive Stack | 12.515mg weekly (therapeutic dose) | 100mg daily | Weekly + daily | Maximal incretin effect + maximal NNMT inhibition | 1624 weeks | Highest theoretical synergy but also highest metabolic stress

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However, as Moncrieff and colleagues point out in an attractive systemic review, there is no convincing evidence that depression could be associated with or caused by lower serotonin concentrations or activity [94]

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