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Lam M, AAl P, Loree JM, Advani SM, Overman MJ, Johnson A, Holla V, Khotskaya Y, Sanchez NS, Meric-Bernstam F, Kopetz S , Pant S

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Increased levels of prostaglandin E2 (PGE 2 ) were demonstrated in homogenized small bowel biopsy specimens from patients with active celiac disease [34] while the levels of the antioxidant enzyme glutathione peroxidase and reductase were decreased in biopsies from celiac disease patients with consequent decreased levels of GSH [35,36,37] (Table 1)

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Moreover, estrogen was reported to regulate proteolysis through the induction of protease inhibitors, preventing excessive degradation of extracellular matrix components that are essential for tissue repair (Horng et al., 2017)