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Sharma M, Sharma R, Jain DK (2016) Nanotechnology based approaches for enhancing oral bioavailability of poorly water soluble antihypertensive drugs

Early studies demonstrated impairment of vasodilation in small blood vessels treated with C(2)-ceramide (109, 110), ceramide (109, 110), or palmitate (111), which corresponded with increased ROS production, decreased eNOS phosphorylation, and decreased NO