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Description

Carcinogenesis 1994, 15:759-762

& Jiri, P

Increased intracellular Ca 2 + concentrations and excessive ROS production lead to elevated mitochondrial Ca 2 + levels, mitochondrial fragmentation, and potential rupture of the mitochondrial membrane

We also demonstrate a novel method for creating glutathione-laden PEGDA microspheres using reverse-phase emulsion polymerization

Further study showed that Tim-AIII promoted HSP90 expression and Tim-AIII induced cell death was blocked by the HSP90 inhibitor tanespimycin, indicating that HSP90 was the main target of Tim-AIII to further trigger intracellular events