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Within this, oral peptides are projected to be a key driver, as consumers demand easier-to-use and non-invasive options

Various strategies can potentially mitigate ferroptosis in AD, such as antioxidant therapy using compounds like vitamin E or Lip-1 to reduce neurodegeneration, iron chelation therapy to control iron levels and limit the generation of ROS, modulation of glutamate signaling pathways to address excitotoxicity, regulation of lipid metabolism to prevent LPO, and activation of GPX4 to safeguard cells against LPO and ferroptosis (Park et al., 2021)

As described earlier, mtDNA may serve as a DAMP capable of propagating the inflammatory response seen in sepsis and a predictive biomarker for ICU-related mortality [16]

This review includes findings from in vitro , in vivo experiments as well as insights from clinical applications, as illustrated in Figure 1