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The warning triggers an inflammatory response to fight the threat, but the excess inflammation that results becomes life-threatening in itself

untreated hypothyroidism can blunt GH response [5]

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In addition, we note that in response to comments in the FY 2021 IPPS/LTCH PPS final rule (85 FR 59015 through 59016), we increased the burden estimate from 15 hours to 20 hours after consideration of comments stating that additional effort would be necessary to crosswalk discharges to an MS-DRG, specifically if a hospital is not familiar with the MS-DRG classification system, for use in calculating the median payer-specific negotiated charges