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Based on this research, docking was performed on the dual copper-binding sites of mTYR and hTYR

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When the drug cannot reach sufficient intracellular concentrations, the cells may survive through intrinsic drug resistance mechanisms and gradually evolve into drug-resistant tumors

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Indeed, microglia are crucial for the elimination of myelin debris by phagocytosis, a prerequisite for remyelination (Napoli and Neumann, 2010

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National Institutes of Health Accessed October 29, 2025

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However, they often show direct RS scavenging or other biological activity (e.g., inhibition of topoisomerase II)

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