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Gastrointestinal effects dominate the tolerability picture Across the Phase 2 obesity, MASH, and diabetes trials, the most consistent finding is a high rate of gastrointestinal adverse events nausea, vomiting, and diarrhea substantially more frequent than placebo

Extract of polygonum cuspidatum attenuates diabetic retinopathy by inhibiting the high-mobility group box-1 (HMGB1) signaling pathway in streptozotocin-induced diabetic rats

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