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Advances in metabolite processing methods and metabolite identification tools, such as Bio-Transformer, are expected to further expand the number of annotated metabolites, enhancing the comprehensive coverage enabled by of metabolic databases (Djoumbou-Feunang et al., 2019

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For instance, studies suggest that the cardioprotective effect of H3K9 methylation may stem from its role in reducing inflammation by inhibiting the MAPK/NF-B signaling pathway [86]