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This was also confirmed in a previous study where in the initial 24 h-period following hepatic I/R injury, the occurrence of AKI was attributed to intrarenal vasoconstriction resulting from splanchnic vasodilatation following portal hypertension 19

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Preconditioning with low doses of thrombin has been shown to attenuate the inflammatory response and prevent cell death in ischemic and hemorrhagic stroke models