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PLoS One 7(12):e52672

When the antioxidant defense system fails to effectively eliminate ROS, these oxidants accumulate precipitously (100), leading to elevated intracellular oxidative stress, which subsequently triggers cuproptosis

Early treatment provides the best chance for improvement

Ross Toole Historical Reflections Rapid, Reliable Riding on Montanas Street Railways by Ellen Baumler The Montana Traveler Wild Horse Island by Diane Tipton Reviews Merrill, ed., Yellowstone and the Great West, reviewed by Chris J

Taken together, the present data suggest that HoloTC is a more sensitive biomarker for the detection of insufficient B 12 supply than any other biomarker and that modestly decreased HoloTC may also indicate the presence of early cellular or functional B 12 deficiency