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Recognizing that individuals may experience pain and functional impairments, the approach to PA must be carefully adapted to each patients specific disease stage and unique needs

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Laboratory and preclinical studies have documented the following research applications and observed effects: Cellular Pathways Studied: Mechanisms of Action: Research Applications: Experimental Models: Research findings contribute to understanding tissue protection mechanisms, angiogenic processes, cellular repair pathways, and peptide-mediated cytoprotection in controlled laboratory environments

9.4 Systematic description of clinical effects 9.4.1 Cardiovascular Acute: - tachycardia and hypotension are common - cardiac arrest may occur and is due to severe hypoxemia (respiratory distress) and/or metabolic acidosis - no direct cardiotoxicity of INH has been reported Chronic: no data available