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DerSimonian R, Laird N

Another recent research in 2021 has reported lower metabolite concentrations of TRP pathway metabolites in both urine ( n = 560) and serum ( n = 354) samples of AD patients [164]

[64] Uniquely, Pitolisant has a novel mechanism of action as an H3 antagonists, which promotes the release of the wakefulness-promoting molecule amine histamine

They observed no difference in this parameter between the presynaptic boutons even under high-intensity stimulation of neurotransmitter release (600AP) [58]