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Another anti-CD38 mAb, Isatuximab, has also shown significant antitumor activity by a more potent action of direct cell killing different from crosslinking, mediated by activation of caspases-7 and 8, lysosome permeabilization, upregulation of reactive oxygen species (ROS), as well as ADCC, CDC, and ADCP mentioned above [80, 81]

Participants with food insecurity were more likely to be White (18% vs 14%), heavy drinkers (13% vs 9%), and have a lower BMI (mean 29 vs 31)

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10.1016/j.molmed.2017.05.006 88