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Crit Rev Toxicology (1993) 23(1):2148

IsoLGs may play roles in aggravating myocardial fibrosis The highly active substance IsoLGs directly bind the lysines of target proteins at an effective concentration of 1/100 of 4-HNE and change the function of the protein (including inhibiting the degradation of LDL and the function of sodium channels and promoting myocardial amyloidosis and the occurrence of AF) [37, 68]