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The proposed mechanism begins with reduced NNMT activity but extends into several interconnected pathways

Two limitations of this study were that it didnt measure muscle protein breakdown and cannot be assumed to necessarily be an accurate picture of muscle retention

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doi: 10.1016/j.ajpath.2013.12.014

In terms of inflammation, MC4R KO mice showed pro-inflammatory gene expression, such as TNF-alpha and IL1-beta in liver and white adipose tissue (WAT), indicating inflammation are activated in liver and WAT (Fig