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Production of pro-inflammatory cytokines and chemokines such as IL-1, IL-6, IL-8, IL-12, IFN-, and TNF induce fever and other signs and symptoms in previously unexposed individuals resulting in severe and fatal malaria (81)

This imbalance leads to the proliferation of mammary gland tissue and hypertrophy of adipose tissue

Notably, ROS play a subtle double-edged sword role in male reproductive physiology: while physiological levels of ROS are essential signaling molecules for normal fertilization processes such as sperm capacitation, hyperactivation, and the acrosome reaction ( 4.1 Imbalance of the oxidative-antioxidant system: multi-source generation and collapse of defense barriers In the pathological microenvironment of CP, the formation of oxidative stress stems from the dual pathological mechanisms of enhanced attack and failed defense, which jointly drive the deterioration of the microenvironment

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Antioxidant therapy for cancer faces challenges such as the dual role of ROS in cancer, redox adaptation in cancer cells, interference with pro-oxidant therapies, and heterogeneous response to antioxidants