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Unlike macrophages, smooth muscle cell death interferes mainly with plaque vulnerability by affecting the components of the fibrous cap on the surface of the plaque (Sampilvanjil et al., 2020)

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ZDHHC20 palmitoylates EGFR on the C-terminal domain (C1025) to promote its ubiquitination-mediated lysosomal degradation, thus upregulating p85 binding and phosphatidylinositol 3-kinase (PI3K) signaling and inhibiting Grb2 binding and MAPK signaling

Deursen, J