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Furthermore, the ATF4/MAP1LC3A/CCPG1 pathway may induce apoptosis via ER autophagy activation ( Regulatory factors in the ovarian microenvironment, such as estradiol (E 2 ), insulin-like growth factor (IGF) (Monniaux and Pisselet, 1992), FSH, and epidermal growth factor (EGF) (Tilly et al., 1992

1.34, National Institute of Health, USA), and the relative Id2/ tubulin band intensity was calculated

Heuer et al

283 Likewise, berberine has been demonstrated to activate the SIRT1/FOXO3/BNIP3 signaling pathway, thereby enhancing cellular autophagy and mitophagy, which are processes essential for clearing damaged mitochondria accumulated in renal tubules under hyperglycemic conditions

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