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Dose response assays demonstrated that RSL3 and ML-210, another GPX4 inhibitor, both had synergistic enhancement of ferroptosis with CMD (Fig

NAPQI is highly reactive and rapidly conjugates with critical cellular enzymes, interfering with normal cellular function and destabilizing the mitochondrial membrane 5

Ghersi-Egea JF, Leninger-Muller B, Suleman G, Siest G, Minn A

ALDH activity for 10 M formaldehyde in hepatic mitochondria from individuals with ALDH2*1/*2 was ~ 30% of that from individuals with functional ALDH2*1/*1 [16]