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However, these treatments often rely on enema or oral administration, which generally suffers from limited rectal retention time, insufficient local drug exposure, or low systemic bioavailability, thus limiting efficacy stability and patient compliance [7, 9]

Dermal papilla (DP) produce growth factors that regulate hair growth/regression 2

For advanced androgenetic alopecia with significant follicle miniaturization, GHK-Cu is best used as part of a comprehensive protocol alongside Minoxidil, DHT blockers, and potentially PRP

They can also block receptors on cancer cells, for example, growth factors