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As evidenced by James et al ., histology from the hyper pigmented area showed irregular epidermal atrophy, absence of basal orientation of epidermal cells, patchy pigmentation of the lower epidermis, and numerous pigment-laden macrophages in the upper dermis and increase of melanin in the basal layer

In parallel, disruptions in folate and B12 metabolism especially via MTHFR polymorphisms , impaired folate receptor function , or cerebral folate deficiency (CFD) are being recognized as both risk modifiers and clinical targets

Researchers note that intranasal delivery may especially increase the bioavailability of peptide therapeutics and present an appealing alternative to injection [14, 15, 16]

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increases red blood cell production