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Retrieved from National Center for Biotechnology Information (NCBI), February 20, 2026

It is the convergence of several adaptive responses, each of which is a normal physiological reaction to weight loss and each of which the GLP-1 medication only partly addresses

Third, constipation and diarrhea, which represent opposing effects on bowel function, both increased with orforglipron treatment, reflecting the complex effects of GLP-1 receptor activation on gut motility, water absorption, and intestinal secretion