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Another exemplary modification is 2'-dimethylaminooxyethoxy, i.e., a 0(CH 2 ) 2 ON(CH 3 ) 2 group, also known as 2'-DMAOE, as described in examples herein below, and 2'-dimethylaminoethoxyethoxy (also known in the art as 2'-0- dimethylaminoethoxyethyl or 2 * -DMAEOE), i.e., 2 * -0-CH 2 -0-CH 2 -N(CH 2 ) 2 , also described in examples herein below