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Vitamin B12 is an essential water-soluble vitamin that is commonly found in a variety of foods such as fish, shellfish, meat, eggs, and dairy products

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New or worsening neurological symptoms (such as progressive numbness, ataxia, or significant cognitive changes) warrant urgent assessment and should not be ignored, as delayed treatment may result in permanent nerve damage

In 2016, FDA issued a warning about lupus erythematosus events and determined the addition of information about systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE) to the labels, which had been reported in patients taking PPIs, including Nexium