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Next, we determined whether hypoxic condition also influenced these metabolites, because the tumor core cells are well known to be exposed to both hypoxia and nutrient starvation, and hypoxic microenvironment plays a critical role in tumor progression and metastasis [29]

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AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

We next explored whether the NRF2 system in SCLC is capable of responding to inhibition of KEAP1, the E3 ligase responsible for regulating NRF2 protein levels

It appears to upregulate genes associated with repair processes while downregulating those linked to inflammation