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However, discontinuing the stack after 12+ weeks can produce a subjective 'crash' period of 710 days characterized by lethargy and appetite suppression as ghrelin signaling re-equilibrates

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We found that double-knockout of KNS1 and MCK1 had additive effects, leading to a more dramatic autophagy defect than either kns1 or the mck1 single knockout (Supplementary Fig