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This mechanism may be associated with pyroptosis-induced mitochondrial ROS release and disruption of membrane integrity

As do other arsenicals, it induces G 2 /M cell cycle arrest and triggers apoptosis through disruption of mitochondrial functions and JNK activation and is responsible for reactive oxygen species production ( FIGURE 4 Darinaparsin was characterized in vitro as a potent inducer of growth arrest and apoptosis in a range of hematologic malignancies such as acute promyelocytic leukemia (APL), acute lymphoblastic leukemia, B cell lymphoma, and multiple myeloma (Matulis et al., 2009)

Likewise, SES treatment reduced the DAI values and improved the histopathology of the colon in the DSS-treated mice, diminishing TNF-, IL-1, and IL-6 production caused by DSS through the modulation of the NF-B and MAPK signaling pathways [469]

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MR-PRESSO applies a leave-one-out approach to identify the genetic variant(s) differentially driving the associations [41], i.e., outliers, and provide a corrected estimate after removing the outliers [42]