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Brain Res 1036:16 Giordano G, Kavanagh TJ, Costa LG (2009) Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71

Folinic acid helps in reduces oxidative stress folate is involved in glutathione production

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Hypoxia signaling also interacts with the PI3K-mTOR pathway and plays an important role [508]

This is a consequence of senescent cells being primed for apoptosis and upregulating antiapoptotic mechanisms to prevent intrinsic 24 and extrinsic 26 apoptosis, which makes them vulnerable to the inhibition of these protective mechanisms