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In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from Tables 1, 2, 3a, and 3b

Research into metabolic decline often reveals a "NAD+ sink," where the body consumes more NAD+ than it can produce, leading to mitochondrial "misfiring" and cellular senescence