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For example, SIRT2 acts as an eraser by removing multiple acyl marks from both histone and nonhistone proteins [175,176,177,178,179], and several metabolic enzymes implicated in disease pathogenesis are known to modulate more than one modification [180]

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Moreover, diagnosis relies heavily on symptom-based exclusion of other disorders (56, 57), since ME/CFS symptoms overlap with many other medical conditions (54)