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Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Lipid oxidation and oxidative damage to mitochondrial DNA further diminish mitochondrial function, establishing a self-perpetuating vicious cycle to exacerbate mitochondrial dysfunction and oxidative stress [80]

Decreased cholesterol levels observed in Smith-Lemli-Optiz Syndrome (SLOS) due to 7-dehydrocholesterol reductase (DHCR7) dysfunction are associated with abnormal developmental myelination 120,121