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Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al

Therefore, folate and cobalamin deficiency may decline hepatic levels of SAMe and phosphatidylcholine (PC) 6

For cell models in need of external metabolizing systems such as S9-mix, NAs are already activated extracellularly and the activated/reactive metabolites must cross both cell and nuclear membranes for DNA adduct formation