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The in vivo rat wound-chamber data, in which injected GHK-Cu increased connective-tissue accumulation in a concentration-dependent way while an inactive control peptide did not, are the systemic-route corroboration of these culture findings and are important because they show the effect surviving the transition from a dish to a living animal

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Even with preservatives, repeatedly dipping a dropper into the vial after touching your face introduces skin floraStaphylococcus epidermidis, Cutibacterium acnesthat secrete proteases