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However, as we delve deeper into the science of this powerful compound, it's essential to consider its implications for kidney function, particularly given the kidneys' unique metabolic environment

In long COVID patients, an excessively increased blood lactate accumulation during exercise has been reported (201)

523 Although the relationship between metformin and AD is contradictory, several clinical studies suggest that long-term metformin therapy is associated with a lower risk of neurodegenerative diseases

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In PD, mutations in GBA, ATP13A2, and PARK9 impair lysosomal function, leading to -synuclein accumulation and cellular toxicity ( In particular, LRRK2 mutations impair endolysosomal trafficking, contributing to -synuclein clearance failure and promoting neurodegeneration ( 3 Epidemiology and global burden of Parkinsons disease Parkinsons disease (PD) is one of the fastest-growing neurological disorders globally, driven primarily by population aging, environmental exposures, and improved longevity