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Description

Holoceruloplasmin is functional and packed into vesicles, the content of which is released at the basolateral side to the circulation, representing the predominant Cu-binding protein in blood (95% of Cu found in plasma) (21-23)

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Gastrointestinal conditions such as pernicious anemia (autoimmune destruction of gastric parietal cells), Crohn's disease, celiac disease, and prior gastric or ileal surgery significantly impair absorption