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Adv Exp Med Biol 583:3747 Dominy JE Jr, Hirschberger LL, Coloso RM, Stipanuk MH (2006b) Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26S proteasome system in the living rat

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PMID: 31538334 J Cell PhysiolTGF-/SMAD4 signaling pathway activates the HAS2-HA system to regulate granulosa cell state

Indeed, ALT telomeres have a relaxed telomeric chromatin configuration (compared to telomerase positive and normal cells) making them more susceptible to DNA damage and telomere elongation through ALT (Lin et al 2021