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In particular, impaired sensory integration and the underlying GABAergic circuits in the IC were rescued in mouse models of ASD by pharmacological enhancement of inhibitory transmission 30

Korangath P, Teo WW, Sadik H, Han L, Mori N, Huijts CM, Wildes F, Bharti S, Zhang Z, Santa-Maria CA, Tsai H, Dang CV, Stearns V, Bhujwalla ZM, Sukumar S

The data collected on the dose range facilitates the selection of doses to investigate the efficacy of the study drug in subsequent phases of the clinical trial