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Two common strategies to overcome the CF mucus barrier are the coating of NPs surface with a dense layer of the so-called muco-inert polymers [i.e., low-molecular-weight polyethylene glycol (PEG)] to eliminate both electrostatic and hydrophobic interactions or the use of mucolytic agents [i.e., N-acetylcysteine (NAC)] to reduce mucosal viscoelasticity (Savla and Minko, 2013

ASO Visual Abstract: Impact of Cancer Care Regionalization on Patient Volume