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Related studies have found (50, 51) that ROS can promote the abnormal proliferation of RA-FLSs and mediate multiple pathological processes including erosion, migration, inflammation, and joint damage

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Histopathological findings The tumor tissue was stained with H&E and other immunohistochemical stains

Teixeira CF, da Cruz IBM, Ribeiro EE, Pillar DM, Turra BO, Praia RS, Barbisan F, Alves AO, Sato DK, Assmann CE, Palma TV, Barcelos RP, Barbosa IM, Azzolin VF (2021) Safety indicators of a novel multi supplement based on guarana, selenium, and L-carnitine: e4vidence from human and red earthworm immune cells