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3.3 Evaluation of the optimal trough voriconazole concentration and voriconazole treatment duration Figure 2 shows the ROC curve related to the incidence of ALI

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Although NAC is often used in the clinic to restore hepatocellular GSH levels to protect against APAP hepatotoxicity, in the context of mitochondrial cholesterol accumulation, which impairs the transport of cytosol GSH into mitochondria, the use of NAC may be inefficient to specifically replenish mGSH stores, requiring the use of permeable GSH prodrugs such as GSH ethyl ester (GSHEE)

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Peixoto et al., 2018)