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-Gal A cleaves the terminal galactose from globotriaosylceramide (Gb3), deficiency of -Gal A leads to progressive accumulation of Gb3 and its analogue lyso-Gb3 (globotriaosylsphingosine) within lysosomes in most cell types, thus affecting different tissues and organs [173,174]

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Guideline Statement 8 The IC/BPS diagnosis should be reconsidered if no improvement occurs after multiple treatment approaches

The escalation typically started at 2 mg weekly for the first 4 weeks, then increased every four weeks in increments of 2 to 4 mg until the target research dose was reached

Mutation in the c-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus