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These results suggest that PIP 2 translocation in response to a low pH environment is a conserved mechanism across vertebrates

Nevertheless, different channels in the same family exhibit varying affinities for PIP 2

Yoshino et al., 1992

33a Coles AJ, Wing M, Smith S, Coraddu F, Greer S, Taylor C, Weetman A, Hale G, Chatterjee VK, Waldmann H, Compston A (1999) Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis