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FK: Conceptualization, Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing original draft, Writing review & editing

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10.1038/srep33052 47 ZengH.JiangY.ChenP.FanX.LiD.LiuA.et al (2013)

Carnitina La carnitina un derivato aminoacidico naturalmente presente nellorganismo, coinvolto nei processi biochimici in particolare nel trasporto degli acidi grassi a lunga catena all'interno dei mitocondri, dove vengono convertiti in energia

In vitro studies showed that pretreatment of human neuroblastoma cells (SH-SY5Y) with melatonin-inhibited oxaliplatin-induced proteolytic activation of caspase-3, inactivation of poly (ADP-ribose) polymerase and DNA damage, thereby rendering resistant apoptotic cells dead, suggesting that melatonin plays a significant role in reducing oxaliplatin-induced neurotoxicity [47]