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When BBB permeability rises, especially in the hippocampus, a large number of cytokines, such as TNF- and IL-6, enter the brain tissue to cause oxidative stress and inflammatory responses in microglia, which plays a major role in the development of cognitive impairment in SAE (Michels et al., 2015b)

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Weeks 5-8: Optimization and Response Assessment The second month represents an optimization phase where protocols may be adjusted based on individual response and tolerance

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This is a request your healthcare provider makes, asking your insurer to approveand therefore coverthe test before its performed