12:e1001843
The mechanism by which topiramate affects the body is by markedly increasing the activity of inhibitory neurotransmitters
Blood Adv 3(2):136147 Seidel MG, Kindle G, Gathmann B, Quinti I, Buckland M, van Montfrans J, Scheible R, Rusch S, Gasteiger LM, Grimbacher B, Mahlaoui N, Ehl S, Abinun M, Albert M, Cohen SB, Bustamante J, Cant A, Casanova JL, Chapel H, de Saint Basile G, de Vries E, Dokal I, Donadieu J, Durandy A, Edgar D, Espanol T, Etzioni A, Fischer A, Gaspar B, Gatti R, Gennery A, Grigoriadou S, Holland S, Janka G, Kanariou M, Klein C, Lachmann H, Lilic D, Manson A, Martinez N, Meyts I, Moes N, Moshous D, Neven B, Ochs H, Picard C, Renner E, Rieux-Laucat F, Seger R, Soresina A, Stoppa-Lyonnet D, Thon V, Thrasher A, van de Veerdonk F, Villa A, Weemaes C, Warnatz K, Wolska B, Zhang SY (2019) The European Society for Immunodeficiencies (ESID) registry working definitions for the clinical diagnosis of inborn errors of immunity
83 Detoxifying enzymes play a crucial role in converting toxic metabolites into less toxic and harmless compounds, facilitating their excretion from the body
It is well-known that regulatory T cells (Tregs) are regarded as protect effect on preventing psoriasis, and excessive ROS would reduce the ratio of Treg: Th17 cells by promoting the proliferation and differentiation of pro-inflammatory Th17/Th1/Th22 cells and reversely suppression of the frequency of Treg to sustain the process of psoriasis [100, 101]
