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Localized to the plasma membrane, FSP1 utilizes NADPH as an electron donor to reduce CoQ10 to its antioxidant form, ubiquinol

Mice were handled in accordance with the NIH Guide for the Care and Use of Laboratory Animals, and experiments were approved by the Fred Hutch Cancer Center Institutional Animal Care and Use Committee and Institutional Review Boards

A little preparation helps your infusion go smoothly and comfortably

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NF-B, PI3K/AKT, and MAPK pathways collectively regulate intracellular GSH and antioxidant capacity, helping tumors evade ROS-dependent therapies