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Male C57BL/6J mice (8 weeks old) were purchased from Chongqing Tengxin Bioscience

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Timing: Can be taken any time of day, with or without food

Lieu CJ, Tran HT, Fiorentino S, Jiang Z, Mao M, Overman MJ, Eng C, Ellis LM, Heymach J, Kopetz S

mutS and mutL alleles contribute to reducing the genetic barrier to recombination (Davidsen and Tnjum, 2006), as it is known that MutS and MutL mismatch binding activity edit (prevent) homologous and homoeologous recombination, limiting the stability of heteroduplex intermediates, with the contribution of the RecBCD nuclease (tambuk and Radman, 1998)