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These anecdotal long-term outcomes suggest that for some EDS patients, prolotherapy serves as a form of maintenance therapy, not a one-time cure, but a reliable way to keep joints functional and pain-controlled by continuously reinforcing the lax ligaments

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As a follow-up, an FDA roadmap has been published, stating that in 35 years time human-relevant testing methods (non-animal New Approach Methods) will be the default for safety/toxicity testing instead of animal studies (218)

Study 2: Interstitial cystitis (2024)

A Message from the Interim Chair Welcome to the Department of Critical Care Medicine at the University of Pittsburgh and UPMC